Sometimes even apoptosis fails: implications for cancer
نویسندگان
چکیده
منابع مشابه
Apoptosis mechanisms: implications for cancer drug discovery.
Defects in the regulation of apoptosis (programmed cell death) make important contributions to the pathogenesis and progression of most cancers and leukemias. Apoptosis defects also figure prominently in resistance to chemotherapy, radiotherapy, hormonal therapy, and immune-based treatments. Apoptosis is caused by activation of intracellular proteases, known as caspases, that are responsible di...
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In applying Bayes’s theorem to the history of science, Bayesians sometimes assume – often without argument – that they can safely ignore very implausible theories. This assumption is false, both in that it can seriously distort the history of science as well as the mathematics and the applicability of Bayes’s theorem. There are intuitively very plausible counter-examples. In fact, one can ignor...
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Programmed cell death is a fundamental aspect of organismal development and stasis through its role in the maintenance of the balance between cell growth and cell death. If the balance is tipped, e.g. by unregulated cell growth, the result can be cancer. If tipped the other direction, e.g. by dysregulated cell death, and the result can again be cancer. The concept of dysregulated cell death, wh...
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Retinoids represent a popular group of differentiation inducers that are successfully used in oncology for treatment of acute promyelocytic leukemia in adults and of neuroblastoma in children. The therapeutic potential of retinoids is based on their key role in the regulation of cell differentiation, growth, and apoptosis, which provides a basis for their use both in cancer therapy and chemopre...
متن کاملApoptosis in cervical cancer cells: implications for adjunct anti-estrogen therapy for cervical cancer.
BACKGROUND Many tumors show dependence on estrogen for growth and establishment of drug resistance. We examined the effects of estrogen on cervical cancer cells exposed to apoptotic agents including drugs used for treatment. MATERIALS AND METHODS We tested the effect of estradiol on apoptosis in three cervical cancer cell lines. Apoptosis was measured by endonucleolytic degradation of DNA. Bc...
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ژورنال
عنوان ژورنال: Molecular & Cellular Oncology
سال: 2020
ISSN: 2372-3556
DOI: 10.1080/23723556.2020.1797430